PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34576795-5	2021	Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis.	Proline	67-74	glutamate 5-kinase	Saccharomyces cerevisiae S288C	168-172	
34576795-5	2021	Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis.	Proline	195-202	glutamate 5-kinase	Saccharomyces cerevisiae S288C	123-127	
34576795-5	2021	Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis.	Proline	195-202	glutamate 5-kinase	Saccharomyces cerevisiae S288C	168-172	
34576795-6	2021	The amino acid change of Gln79 to His in Pro1 resulted in desensitization to the proline-mediated feedback inhibition of GK activity, leading to the accumulation of proline in cells.	Proline	81-88	glutamate 5-kinase	Saccharomyces cerevisiae S288C	41-45	
34576795-6	2021	The amino acid change of Gln79 to His in Pro1 resulted in desensitization to the proline-mediated feedback inhibition of GK activity, leading to the accumulation of proline in cells.	Proline	165-172	glutamate 5-kinase	Saccharomyces cerevisiae S288C	41-45	
34576795-7	2021	Biochemical and in silico analyses showed that the amino acid residue at position 79 is involved in the stabilization of the proline binding pocket in Pro1 via a hydrogen-bonding network, which plays an important role in feedback inhibition.	Proline	125-132	glutamate 5-kinase	Saccharomyces cerevisiae S288C	151-155