PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34259275-0 2021 Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway. Scopolamine 66-77 brain-derived neurotrophic factor Rattus norvegicus 167-171 34259275-2 2021 NDEELNK exerted the neuroprotective effect by improving the acetylcholine (ACh) level and reducing the acetylcholinesterase (AChE) activity in PC12 cells. ndeelnk 0-7 acetylcholinesterase Rattus norvegicus 103-123 34259275-2 2021 NDEELNK exerted the neuroprotective effect by improving the acetylcholine (ACh) level and reducing the acetylcholinesterase (AChE) activity in PC12 cells. ndeelnk 0-7 acetylcholinesterase Rattus norvegicus 125-129 34259275-3 2021 By molecular docking, we confirmed that the NDEELNK backbone and AChE interacted through hydrophobic and hydrogen bonds in contact with the amino acid residues of the cavity wall. Hydrogen 105-113 acetylcholinesterase Rattus norvegicus 65-69 34259275-5 2021 Our results demonstrated that NDEELNK supplementation alleviated scopolamine-induced PC12 cell damage by improving the cholinergic system, increasing energy metabolism and upregulating the expression of phosphorylated protein kinase A (p-PKA), brain-derived neurotrophic factor (BNDF) and nerve growth factor (NGF) signaling proteins in in vitro experiments. Scopolamine 65-76 brain-derived neurotrophic factor Rattus norvegicus 244-277 34259275-5 2021 Our results demonstrated that NDEELNK supplementation alleviated scopolamine-induced PC12 cell damage by improving the cholinergic system, increasing energy metabolism and upregulating the expression of phosphorylated protein kinase A (p-PKA), brain-derived neurotrophic factor (BNDF) and nerve growth factor (NGF) signaling proteins in in vitro experiments. Scopolamine 65-76 brain-derived neurotrophic factor Rattus norvegicus 279-283