PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33903766-2 2021 Here we show that a distinct subset of TAMs (F4/80hiCD115hiC3aRhiCD88hi), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. Heme 101-105 heme oxygenase 1 Homo sapiens 149-165 33903766-2 2021 Here we show that a distinct subset of TAMs (F4/80hiCD115hiC3aRhiCD88hi), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. Heme 101-105 heme oxygenase 1 Homo sapiens 167-171