PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33576217-0	2021	Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line.	Valproic Acid	10-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-106	
33576217-6	2021	Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer.	Valproic Acid	38-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-103	
33576217-6	2021	Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer.	Valproic Acid	38-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-94	
33576217-6	2021	Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer.	Valproic Acid	53-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-103	
33576217-6	2021	Previously, we reported the effect of valproic acid (VPA) and trichostatin A (TSA) on TSGs p21WAF1/CIP1 (p21), p27Kip1 (p27), and p57Kip2 (P57) and also HDAC1 in colon cancer.	Valproic Acid	53-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-94	
33576217-10	2021	RESULTS: VPA downregulated class I histone deacetylase (HDAC) 1, 2, and 3, Bcl-2, Bcl-xL, and Mcl-1 and upregulated p21, p53, Bax, Bak, and Bim resulting in apoptosis induction.	Valproic Acid	9-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	116-119	
33576217-11	2021	CONCLUSION: VPA can induce apoptosis via activation of the intrinsic mitochondrial apoptotic pathway and also epigenetic reactivation of p21 and p53 through inhibition of class I HDAC 1, 2 and 3, activity.<br />.	Valproic Acid	12-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-140