PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33505579-0	2020	Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis.	fucoidan	0-8	NLR family pyrin domain containing 3	Homo sapiens	18-23	
33505579-3	2020	Fucoidan significantly ameliorated lipid accumulation, attenuated progression of carotid atherosclerotic plaques, deregulated the expression of NLRP3 inflammasome, autophagy receptor p62, and upregulated microtubule-associated protein light chain 3 (LC3)-II/I levels.	fucoidan	0-8	NLR family pyrin domain containing 3	Homo sapiens	144-149	
33505579-5	2020	Mechanistically, fucoidan remarkably inhibited NLRP3 inflammasome activation, which was mostly dependent on autophagy.	fucoidan	17-25	NLR family pyrin domain containing 3	Homo sapiens	47-52	
33505579-6	2020	The inhibitory effects of fucoidan on NLRP3 inflammasome were enhanced by autophagy activator rapamycin (Rapa) and alleviated by autophagy inhibitor 3-methyladenine (3-MA).	fucoidan	26-34	NLR family pyrin domain containing 3	Homo sapiens	38-43	
33505579-7	2020	Fucoidan promoted the colocalization of NLRP3 and p62.	fucoidan	0-8	NLR family pyrin domain containing 3	Homo sapiens	40-45	
33505579-8	2020	Knockdown of p62 and ATG5 by small interfering RNA significantly reduced the inhibitory effects of fucoidan treatment on NLRP3 inflammasome.	fucoidan	99-107	NLR family pyrin domain containing 3	Homo sapiens	121-126	
33505579-9	2020	The data suggest that fucoidan can inhibit NLRP3 inflammasome activation by enhancing p62/SQSTM1-dependent selective autophagy to alleviate atherosclerosis.	fucoidan	22-30	NLR family pyrin domain containing 3	Homo sapiens	43-48