PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33454797-0 2021 Brain/blood ratios of methadone and ABCB1 polymorphisms in methadone-related deaths. Methadone 59-68 ATP binding cassette subfamily B member 1 Homo sapiens 36-41 33454797-3 2021 The aims of this study were (1) to determine whether brain/blood ratios can assist in the interpretation of methadone findings in fatalities; (2) to examine whether polymorphisms in the gene encoding the P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1)), which functions as a multispecific efflux pump in the blood-brain barrier, affect brain/blood ratios of methadone. Methadone 432-441 ATP binding cassette subfamily B member 1 Homo sapiens 204-218 33454797-3 2021 The aims of this study were (1) to determine whether brain/blood ratios can assist in the interpretation of methadone findings in fatalities; (2) to examine whether polymorphisms in the gene encoding the P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1)), which functions as a multispecific efflux pump in the blood-brain barrier, affect brain/blood ratios of methadone. Methadone 432-441 ATP binding cassette subfamily B member 1 Homo sapiens 234-264 33454797-10 2021 Our results suggest that the rs1045642 polymorphisms in ABCB1 may affect methadone concentrations in the brain and its site of action and may be an additional factor influencing methadone toxicity. Methadone 73-82 ATP binding cassette subfamily B member 1 Homo sapiens 56-61 33454797-10 2021 Our results suggest that the rs1045642 polymorphisms in ABCB1 may affect methadone concentrations in the brain and its site of action and may be an additional factor influencing methadone toxicity. Methadone 178-187 ATP binding cassette subfamily B member 1 Homo sapiens 56-61