PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33144310-0 2020 Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages. Fatty Acids, Volatile 19-42 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Mus musculus 51-58 33144310-5 2020 Oral supplementation with gut microbiota-derived short-chain fatty acids (SCFAs), subsequently activating G protein-coupled receptor 43 (GPCR43), enhances a macrophage"s capacity to phagocytose invading K. pneumoniae Furthermore, SCFAs and GPR43 increase macrophage bacterial clearance by upregulating LAMTOR2, which is further identified as an antibacterial effector and elucidated to facilitate phagosome-lysosome fusion and extracellular signal-regulated kinase (ERK) phosphorylation. Fatty Acids, Volatile 49-72 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Mus musculus 302-309 33144310-6 2020 Lastly, conditional ablation of Lamtor2 in macrophages decreases their antimicrobial activity, even though mice were pretreated with exogenous SCFA supplementation.IMPORTANCE These observations highlight that SCFAs promote macrophage elimination of K. pneumoniae via a LAMTOR2-dependent signal pathway and suggest that it is possible to intervene in K. pneumoniae pneumonia by targeting the gut microbiota. Fatty Acids, Volatile 143-147 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Mus musculus 32-39