PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33139730-1 2020 Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Tamoxifen 110-119 cyclin D1 Homo sapiens 0-9 33139730-2 2020 Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Tamoxifen 90-99 cyclin D1 Homo sapiens 56-65 33139730-5 2020 High expression of DILA1 is associated with overexpressed Cyclin D1 protein and poor prognosis in breast cancer patients who received tamoxifen treatment. Tamoxifen 134-143 cyclin D1 Homo sapiens 58-67 33139730-6 2020 This study shows the previously unappreciated importance of post-translational dysregulation of Cyclin D1 contributing to tamoxifen resistance in breast cancer. Tamoxifen 122-131 cyclin D1 Homo sapiens 96-105 33139730-7 2020 Moreover, it reveals the novel mechanism of DILA1 in regulating Cyclin D1 protein stability and suggests DILA1 is a specific therapeutic target to downregulate Cyclin D1 protein and reverse tamoxifen resistance in treating breast cancer. Tamoxifen 190-199 cyclin D1 Homo sapiens 64-73