PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33009372-3 2020 Here, we have identified that the depletion of the mTOR gene in the mice striatum completely prevented the extrapyramidal motor side effects (catalepsy) induced by the dopamine 2 receptor (D2R) antagonist haloperidol, which is the most widely used typical antipsychotic drug. Haloperidol 205-216 dopamine receptor D2 Mus musculus 168-187 33009372-3 2020 Here, we have identified that the depletion of the mTOR gene in the mice striatum completely prevented the extrapyramidal motor side effects (catalepsy) induced by the dopamine 2 receptor (D2R) antagonist haloperidol, which is the most widely used typical antipsychotic drug. Haloperidol 205-216 dopamine receptor D2 Mus musculus 189-192 33009372-8 2020 Collectively, our data indicate that striatal mTORC1 blockade may offer therapeutic benefits with regard to the prevention of D2R-dependent extrapyramidal motor side effects of haloperidol in psychiatric illness. Haloperidol 177-188 dopamine receptor D2 Mus musculus 126-129