PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32918543-4 2020 In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE). Proline 22-29 peptidase D Homo sapiens 77-86 32918543-4 2020 In order to targeting proline for PRODH/POX-dependent pathways substrate for prolidase, glycyl-proline (GP) was provided and proline utilization for collagen biosynthesis was blocked using 2-methoxyestradiol (MOE). Proline 95-102 peptidase D Homo sapiens 77-86 32918543-10 2020 RESULTS: Prolidase overexpression in MCF-7PL cells contributed to 10-fold increase in the enzyme activity, 3-fold increase in cytoplasmic proline level and decrease in cell viability and DNA biosynthesis compared to wild type MCF-7 cells. Proline 138-145 peptidase D Homo sapiens 9-18 32918543-16 2020 CONCLUSION: The data suggest that overexpression of prolidase in MCF-7 cells contributes to increase in intracellular proline concentration and PRODH/POX-dependent autophagic cell death. Proline 118-125 peptidase D Homo sapiens 52-61