PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32758662-0	2020	The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils.	Reactive Oxygen Species	42-65	cytochrome b-245 beta chain	Homo sapiens	96-104	
32758662-0	2020	The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils.	Reactive Oxygen Species	42-65	cytochrome b-245 beta chain	Homo sapiens	105-109	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	cytochrome b-245 beta chain	Homo sapiens	107-115	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	cytochrome b-245 beta chain	Homo sapiens	119-123	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	cytochrome b-245 alpha chain	Homo sapiens	128-135	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	neutrophil cytosolic factor 1	Homo sapiens	167-174	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	neutrophil cytosolic factor 2	Homo sapiens	176-183	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	neutrophil cytosolic factor 4	Homo sapiens	185-192	
32758662-4	2020	Superoxide is produced by the phagocyte NADPH oxidase, a complex enzyme composed of two membrane subunits, gp91phox or NOX2 and p22phox, and four cytosolic components p47phox, p67phox, p40phox, and Rac2.	Superoxides	0-10	Rac family small GTPase 2	Homo sapiens	198-202	
32758662-6	2020	Here we show that forskolin, an activator of the adenylate cyclase-cAMP-PKA pathway, induced phosphorylation of gp91phox/NOX2 and inhibited fMLF-induced NADPH oxidase activation in human neutrophils.	Colforsin	18-27	cytochrome b-245 beta chain	Homo sapiens	112-120	
32758662-6	2020	Here we show that forskolin, an activator of the adenylate cyclase-cAMP-PKA pathway, induced phosphorylation of gp91phox/NOX2 and inhibited fMLF-induced NADPH oxidase activation in human neutrophils.	Colforsin	18-27	cytochrome b-245 beta chain	Homo sapiens	121-125	
32758662-6	2020	Here we show that forskolin, an activator of the adenylate cyclase-cAMP-PKA pathway, induced phosphorylation of gp91phox/NOX2 and inhibited fMLF-induced NADPH oxidase activation in human neutrophils.	Cyclic AMP	67-71	cytochrome b-245 beta chain	Homo sapiens	112-120	
32758662-7	2020	H89, a PKA inhibitor prevented the forskolin-induced phosphorylation of gp91phox and restored NADPH oxidase activation.	Colforsin	35-44	cytochrome b-245 beta chain	Homo sapiens	72-80	
32758662-8	2020	Furthermore, PKA phosphorylated the recombinant gp91phox/NOX2-cytosolic C-terminal region in vitro only on a few specific peptides containing serine residues, as compared to PKC.	Serine	142-148	cytochrome b-245 beta chain	Homo sapiens	48-56	
32758662-8	2020	Furthermore, PKA phosphorylated the recombinant gp91phox/NOX2-cytosolic C-terminal region in vitro only on a few specific peptides containing serine residues, as compared to PKC.	Serine	142-148	cytochrome b-245 beta chain	Homo sapiens	57-61	
32758662-11	2020	These results suggest that PKA phosphorylates NOX2 in human neutrophils, a process essential to limit ROS production and inflammation under physiological conditions.	Reactive Oxygen Species	102-105	cytochrome b-245 beta chain	Homo sapiens	46-50	
32758662-12	2020	Our data identify cAMP-PKA-NOX2-axis as a critical gatekeeper of neutrophil ROS production.	Cyclic AMP	18-22	cytochrome b-245 beta chain	Homo sapiens	27-31	
32758662-12	2020	Our data identify cAMP-PKA-NOX2-axis as a critical gatekeeper of neutrophil ROS production.	Reactive Oxygen Species	76-79	cytochrome b-245 beta chain	Homo sapiens	27-31