PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32049985-1	2020	The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells.	Iodides	11-17	solute carrier family 5 member 5	Homo sapiens	29-32	
32049985-4	2020	Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to malignant transformation.	Iodides	57-63	solute carrier family 5 member 5	Homo sapiens	10-13	
32049985-11	2020	Additionally, TNF-alpha and PMA were shown to have a negative impact on TSH-induced iodide uptake, consistent with the observed transcriptional downregulation of NIS.	Iodides	84-90	solute carrier family 5 member 5	Homo sapiens	162-165	
32049985-13	2020	A better understanding of the mechanisms underlying NIS expression in the context of normal thyroid physiology may guide the development of pharmacological strategies to increase the efficiency of iodide uptake.	Iodides	197-203	solute carrier family 5 member 5	Homo sapiens	52-55