PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31612866-7	2019	nAChRalpha1 knockdown significantly decreases the nicotine-induced upregulation of p-STAT3, p-Akt and p-mTOR in vitro, while nAChRalpha1 overexpression has the opposite effects.	Nicotine	50-58	thymoma viral proto-oncogene 1	Mus musculus	94-97	
31612866-9	2019	Moreover, there is a direct interaction between STAT3 and nAChRalpha1 that modulates STAT3 nuclear translocation and its binding to the Akt promoter region upon nicotine exposure.	Nicotine	161-169	thymoma viral proto-oncogene 1	Mus musculus	136-139	
31612866-10	2019	Taken together, STAT3 and nAChRalpha1 blockade attenuates nicotine-induced atherosclerosis by reducing the migration and proliferation of vascular smooth muscle cells and inflammation in macrophages via the Akt/mTOR pathway.	Nicotine	58-66	thymoma viral proto-oncogene 1	Mus musculus	207-210