PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31383668-4 2019 As shown by gene deletion experiments, the decreased susceptibility of the mutants to aminoglycosides was independent from operon arn but required the efflux system MexXY(OprM) and the products of three genes, PA4773-PA4774-PA4775, that are cotranscribed and activated with genes pmrAB Gene PA4773 (annotated as speD2 in PAO1 genome) and PA4774 (speE2) are predicted to encode enzymes involved in biosynthesis of polyamines. Aminoglycosides 86-101 outer membrane protein OprM Pseudomonas aeruginosa PAO1 171-175 31383668-6 2019 Altogether, our results suggest that norspermidine decreases the self-promoted uptake pathway of aminoglycosides across the outer membrane and thereby potentiates the activity of efflux pump MexXY(OprM). Aminoglycosides 97-112 outer membrane protein OprM Pseudomonas aeruginosa PAO1 197-201