PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31353565-5 2019 Three peptides (EW, ADGF, and DWDPK) inhibited the morphological changes, downregulated the content of lactate dehydrogenase and malondialdehyde, upregulated the activity of antioxidant enzymes catalase, total superoxide dismutase and glutathione peroxidase, and scavenged reactive oxygen species (ROS) in HUVECs. Malondialdehyde 129-144 adenosine deaminase 2 Homo sapiens 20-24 31353565-6 2019 Quantitative reverse transcriptive polymerase chain reaction and western blot assays indicated that these three peptides regulated NADPH oxidase activity and ROS production by reducing NOX4 and p22phox levels. Reactive Oxygen Species 158-161 NADPH oxidase 4 Homo sapiens 185-189 31353565-6 2019 Quantitative reverse transcriptive polymerase chain reaction and western blot assays indicated that these three peptides regulated NADPH oxidase activity and ROS production by reducing NOX4 and p22phox levels. Reactive Oxygen Species 158-161 cytochrome b-245 alpha chain Homo sapiens 194-201 31353565-10 2019 Our results indicate that hazelnut peptides (EW, ADGF, and DWDPK) can ensure normal growth of cells by protecting important antioxidant enzyme systems, by enhancing antioxidant defense, by directly affecting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and by reducing intracellular reactive oxygen species (ROS) production in HUVECs, indicating that the three antioxidative peptides have a protective effect against Ang II-induced oxidative stress injury. NADP 208-251 adenosine deaminase 2 Homo sapiens 49-53