PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31131313-2 2019 We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression. Proline 112-119 pyrroline-5-carboxylate reductase 1 Homo sapiens 223-258 31131313-2 2019 We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression. Proline 112-119 pyrroline-5-carboxylate reductase 1 Homo sapiens 259-264