PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30614034-0 2019 Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Etoposide 45-54 tumor protein p53 Homo sapiens 29-32 30614034-4 2019 The time course study showed that the expression of FHIT, p53, and p38MAPK started after 1 hour following etoposide treatment. Etoposide 106-115 tumor protein p53 Homo sapiens 58-61 30614034-8 2019 Thus, activation of p38 upon etoposide treatment leads to increase in FHIT and p53 expression. Etoposide 29-38 tumor protein p53 Homo sapiens 79-82 30614034-9 2019 In p53 knockdown MCF-7, the FHIT induction was hampered but p38 activation was induced in lower doses of etoposide. Etoposide 105-114 tumor protein p53 Homo sapiens 3-6 30614034-11 2019 Our data demonstrated that the exposure of MCF-7 cells to etoposide increases apoptosis through a mechanism involving the activation of the p38-FHIT-p53 pathway. Etoposide 58-67 tumor protein p53 Homo sapiens 149-152