PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30442142-0	2018	Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1.	Metformin	0-9	tumor protein p53	Homo sapiens	61-64	
30442142-5	2018	We later clarified the effect of metformin on p53 protein stability using transient transfection and cycloheximide chase analyses.	Metformin	33-42	tumor protein p53	Homo sapiens	46-49	
30442142-6	2018	RESULTS: We observed that metformin represses cell cycle progression, thereby inducing subG1 populations, and had induced apoptosis through downregulation of p53 protein and a target gene, differentiated embryo chondrocyte 1 (DEC1).	Metformin	26-35	tumor protein p53	Homo sapiens	158-161	
30442142-9	2018	Examination of the mechanisms underlying metformin-induced HeLa cell death revealed that reduced stability of p53 in metformin-treated cells leads to decreases in DEC1 and induction of apoptosis.	Metformin	41-50	tumor protein p53	Homo sapiens	110-113	
30442142-9	2018	Examination of the mechanisms underlying metformin-induced HeLa cell death revealed that reduced stability of p53 in metformin-treated cells leads to decreases in DEC1 and induction of apoptosis.	Metformin	117-126	tumor protein p53	Homo sapiens	110-113	
30442142-10	2018	CONCLUSION: The involvement of DEC1 provides new insight into the positive or negative functional roles of p53 in the metformin-induced cytotoxicity in tumor cells.	Metformin	118-127	tumor protein p53	Homo sapiens	107-110