PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30365089-3 2019 The mechanistic studies confirmed that the enhancement of Snail1 expression in bortezomib-resistant MMCs directly upregulated transcription of the intracellular MDR1 gene to immediately develop multiple drug resistance mechanisms and inhibited P53 protein expression through the Snail1/hsa-miRNA-22-3p/P53 pathway to inhibit tumor cell apoptosis. Bortezomib 79-89 tumor protein p53 Homo sapiens 244-247 30365089-3 2019 The mechanistic studies confirmed that the enhancement of Snail1 expression in bortezomib-resistant MMCs directly upregulated transcription of the intracellular MDR1 gene to immediately develop multiple drug resistance mechanisms and inhibited P53 protein expression through the Snail1/hsa-miRNA-22-3p/P53 pathway to inhibit tumor cell apoptosis. Bortezomib 79-89 tumor protein p53 Homo sapiens 302-305