PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29648801-2	2018	Proline biosynthesis and degradation involve the shared intermediate Delta1-pyrroline-5-carboxylate (P5C), which forms l-glutamate-gamma-semialdehyde (GSAL) in a reversible non-enzymatic reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	75-99	
29648801-2	2018	Proline biosynthesis and degradation involve the shared intermediate Delta1-pyrroline-5-carboxylate (P5C), which forms l-glutamate-gamma-semialdehyde (GSAL) in a reversible non-enzymatic reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	101-104	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-67	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-67	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	0-7	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-67	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-67	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Proline	89-96	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119	
29648801-6	2018	PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways.	Proline	58-65	pyrroline-5-carboxylate reductase 1	Homo sapiens	10-14	
29648801-6	2018	PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways.	Proline	58-65	pyrroline-5-carboxylate reductase 1	Homo sapiens	66-69	
29648801-7	2018	The proline-P5C cycle has been implicated in supporting ATP production, protein and nucleotide synthesis, anaplerosis, and redox homeostasis in cancer cells.	Proline	4-11	pyrroline-5-carboxylate reductase 1	Homo sapiens	12-15	
29648801-8	2018	This Perspective details the structures and reaction mechanisms of PRODH and PYCR and the role of the proline-P5C cycle in cancer metabolism.	Proline	102-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	110-113	
29648801-9	2018	A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer.	Proline	136-143	pyrroline-5-carboxylate reductase 1	Homo sapiens	92-96	
29648801-9	2018	A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer.	Proline	180-187	pyrroline-5-carboxylate reductase 1	Homo sapiens	188-191	
29648801-10	2018	These molecular probes could also serve as lead compounds in cancer drug discovery targeting the proline-P5C cycle.	Proline	97-104	pyrroline-5-carboxylate reductase 1	Homo sapiens	105-108