PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29242562-0	2017	ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.	Reactive Oxygen Species	0-3	caspase 8	Homo sapiens	34-43	
29242562-3	2017	Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-induced apoptosis in the HCT116 human colon cancer cell line.	Reactive Oxygen Species	122-125	caspase 8	Homo sapiens	109-118	
29242562-7	2017	Furthermore, siRNA-mediated knockdown of caspase-8 blocked the ROS-induced decrease in NHLRC2 protein levels.	Reactive Oxygen Species	63-66	caspase 8	Homo sapiens	41-50	
29242562-9	2017	These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis.	Reactive Oxygen Species	34-37	caspase 8	Homo sapiens	58-67	
29242562-9	2017	These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis.	Reactive Oxygen Species	229-232	caspase 8	Homo sapiens	58-67