PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29122594-0 2018 Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux. Cholesterol 132-143 NLR family pyrin domain containing 3 Homo sapiens 18-23 29122594-4 2018 Inhibition of the NLRP3 inflammasome attenuated foam cell formation, diminished ox-LDL uptake, and promoted cholesterol efflux from THP-1 macrophages. Cholesterol 108-119 NLR family pyrin domain containing 3 Homo sapiens 18-23 29122594-6 2018 Collectively, our findings show that inhibition of the NLRP3 inflammasome decreases foam cell formation of THP-1 macrophages via suppression of ox-LDL uptake and enhancement of cholesterol efflux, which may be due to downregulation of CD36 expression and upregulation of ABCA1 and SR-BI expression, respectively. Cholesterol 177-188 NLR family pyrin domain containing 3 Homo sapiens 55-60