PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28942439-0 2017 Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model. Proline 41-48 proline dehydrogenase 1 Homo sapiens 79-84 28942439-0 2017 Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model. Proline 41-48 proline dehydrogenase 1 Homo sapiens 85-88 28942439-1 2017 BACKGROUND/AIMS: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Proline 54-61 proline dehydrogenase 1 Homo sapiens 118-127 28942439-9 2017 RESULTS: PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells. Proline 125-132 proline dehydrogenase 1 Homo sapiens 9-14 28942439-9 2017 RESULTS: PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells. Proline 125-132 proline dehydrogenase 1 Homo sapiens 15-18 28942439-9 2017 RESULTS: PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells. Proline 125-132 proline dehydrogenase 1 Homo sapiens 155-158 28942439-12 2017 All the compounds inhibited collagen biosynthesis, increased prolidase activity and cytoplasmic proline level in MCF-7shPRODH/POX cells and contributed to the induction of pro-survival mode only in MCF-7shPRODH/POX cells. Proline 96-103 proline dehydrogenase 1 Homo sapiens 126-129 28942439-14 2017 CONCLUSION: PRODH/POX was confirmed as a driver of apoptosis and proved the eligibility of MCF-7shPRODH/POX cell line as a highly effective model to elucidate the different mechanisms underlying proline utilization or generation in PRODH/POX-dependent pro-apoptotic pathways. Proline 195-202 proline dehydrogenase 1 Homo sapiens 12-17 28942439-14 2017 CONCLUSION: PRODH/POX was confirmed as a driver of apoptosis and proved the eligibility of MCF-7shPRODH/POX cell line as a highly effective model to elucidate the different mechanisms underlying proline utilization or generation in PRODH/POX-dependent pro-apoptotic pathways. Proline 195-202 proline dehydrogenase 1 Homo sapiens 18-21 28942439-14 2017 CONCLUSION: PRODH/POX was confirmed as a driver of apoptosis and proved the eligibility of MCF-7shPRODH/POX cell line as a highly effective model to elucidate the different mechanisms underlying proline utilization or generation in PRODH/POX-dependent pro-apoptotic pathways. Proline 195-202 proline dehydrogenase 1 Homo sapiens 98-103