PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28859968-0 2017 Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure. saxagliptin 61-72 dipeptidyl peptidase 4 Homo sapiens 0-22 28859968-3 2017 We found that the primary target of saxagliptin, dipeptidyl peptidase-4, is absent in cardiomyocytes, yet saxagliptin internalized into cardiomyocytes and impaired cardiac contractility via inhibition of the Ca2+/calmodulin-dependent protein kinase II-phospholamban-sarcoplasmic reticulum Ca2+-ATPase 2a axis and Na+-Ca2+ exchanger function in Ca2+ extrusion. saxagliptin 36-47 dipeptidyl peptidase 4 Homo sapiens 49-71