PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28844085-8 2018 Nicotinamide, a PARP-1 inhibitor, protects against the metabolic cascade elicited by the primary stage, avoiding NAD+ exhaustion and the energetic crisis. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 16-22 28844085-11 2018 Here, we discuss evidence showing that (i) inhibition of PARP-1 overactivation by nicotinamide and (ii) inhibition of extrasynaptic NMDA receptor overactivation by memantine can prevent the short- and long-term consequences of PA. Niacinamide 82-94 poly (ADP-ribose) polymerase 1 Rattus norvegicus 57-63