PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28767701-1	2017	OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways.	Cyclic AMP	110-140	adenylate cyclase 6	Mus musculus	36-64	
28767701-1	2017	OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways.	Cyclic AMP	142-146	adenylate cyclase 6	Mus musculus	36-64	
28767701-1	2017	OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways.	Cyclic AMP	162-166	adenylate cyclase 6	Mus musculus	36-64	
28767701-2	2017	We previously generated a catalytically inactive mutant of AC6 (AC6mut) that has an attenuated response to beta-adrenergic receptor stimulation, and, consequently, exhibits reduced myocardial cAMP generation.	Cyclic AMP	192-196	adenylate cyclase 6	Mus musculus	59-62	
28767701-2	2017	We previously generated a catalytically inactive mutant of AC6 (AC6mut) that has an attenuated response to beta-adrenergic receptor stimulation, and, consequently, exhibits reduced myocardial cAMP generation.	Cyclic AMP	192-196	adenylate cyclase 6	Mus musculus	64-70	
28767701-5	2017	Isoproterenol infusion caused deleterious effects that were attenuated by cardiac-directed AC6mut expression.	Isoproterenol	0-13	adenylate cyclase 6	Mus musculus	91-97	
28767701-7	2017	In addition, AC6mut mice showed superior left ventricular function, manifested by higher values for LV peak +dP/dt (p = 0.03), LV peak -dP/dt (p = 0.008), end-systolic pressure-volume relationship (p = 0.003) and cardiac output (p<0.03).	dp	109-111	adenylate cyclase 6	Mus musculus	13-19	
28767701-7	2017	In addition, AC6mut mice showed superior left ventricular function, manifested by higher values for LV peak +dP/dt (p = 0.03), LV peak -dP/dt (p = 0.008), end-systolic pressure-volume relationship (p = 0.003) and cardiac output (p<0.03).	dp	136-138	adenylate cyclase 6	Mus musculus	13-19	
28767701-7	2017	In addition, AC6mut mice showed superior left ventricular function, manifested by higher values for LV peak +dP/dt (p = 0.03), LV peak -dP/dt (p = 0.008), end-systolic pressure-volume relationship (p = 0.003) and cardiac output (p<0.03).	Thymidine	112-114	adenylate cyclase 6	Mus musculus	13-19	
28767701-10	2017	CONCLUSION: Mice with cardiac-directed AC6mut expression weathered the deleterious effects of continuous isoproterenol infusion better than control mice, indicating cardiac protection.	Isoproterenol	105-118	adenylate cyclase 6	Mus musculus	39-45