PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2845924-0	1988	Synergism between thrombin and adrenaline (epinephrine) in human platelets.	Epinephrine	43-54	coagulation factor II, thrombin	Homo sapiens	18-26	
2845924-4	1988	Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml).	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	172-180	
2845924-4	1988	Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml).	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	222-230	
2845924-5	1988	The thrombin-induced hydrolysis of inositol phospholipids by phospholipase C, which was measured as the formation of [32P]PA, was potentiated by adrenaline, as was the increase in the levels of [32P]PIP2 and [32P]PIP.	Epinephrine	145-155	coagulation factor II, thrombin	Homo sapiens	4-12	
2845924-6	1988	The presence of adrenaline caused a shift to the left for the thrombin-induced changes in the phosphoinositide metabolism, without affecting the maximal levels of 32P-labelled compounds obtained.	Epinephrine	16-26	coagulation factor II, thrombin	Homo sapiens	62-70	
2845924-7	1988	A similar shift by adrenaline in the dose-response relationship was previously demonstrated for thrombin-induced aggregation and dense-granule secretion.	Epinephrine	19-29	coagulation factor II, thrombin	Homo sapiens	96-104	
2845924-8	1988	Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion).	Epinephrine	64-74	coagulation factor II, thrombin	Homo sapiens	44-52	
2845924-8	1988	Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion).	Epinephrine	64-74	coagulation factor II, thrombin	Homo sapiens	87-95	
2845924-9	1988	Our observations clearly indicate that adrenaline directly or indirectly influences thrombin-induced changes in phosphoinositide metabolism.	Epinephrine	39-49	coagulation factor II, thrombin	Homo sapiens	84-92