PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27618097-0 2016 Effects of Folic Acid on Secretases Involved in Abeta Deposition in APP/PS1 Mice. Folic Acid 11-21 amyloid beta (A4) precursor protein Mus musculus 48-53 27618097-4 2016 Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid. Folic Acid 32-38 amyloid beta (A4) precursor protein Mus musculus 59-64 27618097-4 2016 Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid. Folic Acid 124-134 amyloid beta (A4) precursor protein Mus musculus 59-64 27618097-5 2016 In the present study, we aimed to investigate whether folic acid could influence the generation of Abeta by regulating alpha-, beta-, and gamma-secretase. Folic Acid 54-64 amyloid beta (A4) precursor protein Mus musculus 99-104 27618097-10 2016 Taken together, the effect of folic acid on Abeta deposition may relate to making APP metabolism through non-amyloidogenic pathway by decreasing beta-secretase and increasing alpha-secretase. Folic Acid 30-40 amyloid beta (A4) precursor protein Mus musculus 44-49