PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27609465-0	2016	Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines.	Oxaliplatin	26-37	tumor protein p53	Homo sapiens	57-60	
27609465-3	2016	In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or p53-/- HCT116 cells, which all lack p53 expression.	Oxaliplatin	22-33	tumor protein p53	Homo sapiens	111-114	
27609465-3	2016	In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or p53-/- HCT116 cells, which all lack p53 expression.	Oxaliplatin	22-33	tumor protein p53	Homo sapiens	169-172	
27609465-3	2016	In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or p53-/- HCT116 cells, which all lack p53 expression.	Oxaliplatin	22-33	tumor protein p53	Homo sapiens	169-172	
27609465-4	2016	Administration of oxaliplatin significantly induced p53 accumulation and enhanced expression of CYP2S1 in HCT116 cells with wild-type p53.	Oxaliplatin	18-29	tumor protein p53	Homo sapiens	52-55	
27609465-4	2016	Administration of oxaliplatin significantly induced p53 accumulation and enhanced expression of CYP2S1 in HCT116 cells with wild-type p53.	Oxaliplatin	18-29	tumor protein p53	Homo sapiens	134-137	
27609465-6	2016	Interestingly, enzyme immunoassays, TOPFlash/FOPFlash reporter activity assays and western blotting analysis demonstrated oxaliplatin-mediated downregulation of PGE2 and Wnt/beta-catenin signaling in a manner dependent on p53.	Oxaliplatin	122-133	tumor protein p53	Homo sapiens	222-225	
27609465-8	2016	These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner.	Oxaliplatin	27-38	tumor protein p53	Homo sapiens	131-134