PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27605212-0 2017 Activation of G0S2 is coordinated by recruitment of PML/RARalpha and C/EBPepsilon to its promoter during ATRA-induced APL differentiation. Tretinoin 105-109 PML nuclear body scaffold Homo sapiens 52-55 27605212-1 2017 All-trans retinoic acid (ATRA) binds the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion protein and is an effective oncogene-targeted therapy for acute promyelocytic leukemia (APL). Tretinoin 0-23 PML nuclear body scaffold Homo sapiens 94-97 27605212-1 2017 All-trans retinoic acid (ATRA) binds the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion protein and is an effective oncogene-targeted therapy for acute promyelocytic leukemia (APL). Tretinoin 25-29 PML nuclear body scaffold Homo sapiens 94-97 27605212-2 2017 However, the molecular basis of PML/RARalpha-mediated transcriptional control during ATRA-induced differentiation is unclear. Tretinoin 85-89 PML nuclear body scaffold Homo sapiens 32-35 27605212-4 2017 Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. Tretinoin 236-240 PML nuclear body scaffold Homo sapiens 165-168 27605212-4 2017 Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. Tretinoin 236-240 PML nuclear body scaffold Homo sapiens 187-190 27605212-4 2017 Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. Tretinoin 303-307 PML nuclear body scaffold Homo sapiens 165-168 27605212-4 2017 Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. Tretinoin 303-307 PML nuclear body scaffold Homo sapiens 187-190