PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27565568-0	2016	Rapid LC-MS/MS method for the determination of 4-hydroxycholesterol/cholesterol ratio in serum as endogenous biomarker for CYP3A activity in human and foals.	cholest-5-ene-3,4-diol	47-67	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	123-128	
27565568-2	2016	Thus, it was the aim of this study to develop and validate an analytical method allowing estimation of the hepatic CYP3A enzyme activity using the 4-hydroxycholesterol to cholesterol ratio as an endogenous biomarker in serum.	cholest-5-ene-3,4-diol	147-167	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-120	
27565568-11	2016	Finally, the validated assay was applied to measure 4-hydroxycholesterol and cholesterol in serum samples of clinical studies in humans and foals that could verify induction of hepatic CYP3A4 (human) and CYP3A89 (foals) after premedication with the known enzyme inducer rifampicin.	cholest-5-ene-3,4-diol	52-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	185-191