PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27481946-1 2016 Downstream of receptor tyrosine kinase and G protein-coupled receptor (GPCR) stimulation, the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho GTPases, leading to important roles for PREX proteins in numerous cellular processes and diseases, including cancer. phosphatidylinositol 3,4,5-triphosphate 94-134 ret proto-oncogene Homo sapiens 14-38