PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27401064-3	2017	Based on multiaspect roles of Rho kinase inhibitor Fasudil on neuroprotection, neurorepair and immunomodulation, we observed therapeutic potential of Fasudil and explored possible mechanisms in amyloid precursor protein/ presenilin-1 transgenic (APP/PS1 Tg) mice, an animal model of Alzheimer"s disease.	fasudil	150-157	amyloid beta (A4) precursor protein	Mus musculus	194-219	
27401064-8	2017	RESULTS: Fasudil treatment ameliorated learning and memory deficits, accompanied by reduced Abeta deposition, Tau protein phosphorylation, and BACE expression, as well as increased PSD-95 expression in hippocampus.	fasudil	9-16	amyloid beta (A4) precursor protein	Mus musculus	92-97	
27401064-11	2017	The study provides preclinical evidence that Fasudil treatment ameliorated memory deficits in APP/PS1 Tg mice, accompanied by the reduction of Abeta deposition and Tau protein phosphorylation, the decrease of BACE and the increase of PSD-95, as well as inhibition of TLRs-NF-kappaB-MyD88 inflammatory cytokine axis.	fasudil	45-52	amyloid beta (A4) precursor protein	Mus musculus	143-148