PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27234893-3 2016 The new sulfonamides showed excellent inhibition of all three isoforms, with KIs in the range of 0.84-702nM against hCA I, of 0.41-288nM against hCA II and of 5.6-29.2 against the tumor-associated hCA IX, a validated anti-tumor target, with a sulfonamide (SLC-0111) in Phase I clinical trials for the treatment of hypoxic, metastatic solid tumors overexpressing CA IX. Sulfonamides 8-20 carbonic anhydrase 9 Homo sapiens 198-203 27234893-3 2016 The new sulfonamides showed excellent inhibition of all three isoforms, with KIs in the range of 0.84-702nM against hCA I, of 0.41-288nM against hCA II and of 5.6-29.2 against the tumor-associated hCA IX, a validated anti-tumor target, with a sulfonamide (SLC-0111) in Phase I clinical trials for the treatment of hypoxic, metastatic solid tumors overexpressing CA IX. Sulfonamides 8-19 carbonic anhydrase 9 Homo sapiens 198-203