PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27191787-2	2016	There are four major genetic defects (SLC19A2, SLC19A3, SLC25A19 and TPK1) involved in the metabolism and transport of thiamine through cellular and mitochondrial membranes.	Thiamine	119-127	solute carrier family 19 member 3	Homo sapiens	47-54	
27191787-6	2016	Expert commentary: Doses of thiamine vary according to the genetic defect: for SLC19A2, the usual dose is 25-200 mg/day (1-4 mg/kg per day), for SLC19A3, 10-40 mg/kg per day, and for TPK1, 30 mg/kg per day.	Thiamine	28-36	solute carrier family 19 member 3	Homo sapiens	145-152	
27191787-7	2016	Thiamine supplementation in SLC19A3-mutated patients restores CSF and intracellular thiamine levels, resulting in successful clinical benefits.	Thiamine	0-8	solute carrier family 19 member 3	Homo sapiens	28-35	
27191787-7	2016	Thiamine supplementation in SLC19A3-mutated patients restores CSF and intracellular thiamine levels, resulting in successful clinical benefits.	Thiamine	84-92	solute carrier family 19 member 3	Homo sapiens	28-35	
27191787-8	2016	In conclusion, evidence collected so far suggests that the administration of thiamine improves outcome in SLC19A-2, SLC19A3- and TPK1-mutated patients, so most efforts should be aimed at early diagnosis of these disorders.	Thiamine	77-85	solute carrier family 19 member 3	Homo sapiens	116-123