PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27133199-0 2016 Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. Scopoletin 0-10 vascular endothelial growth factor A Homo sapiens 144-150 27133199-12 2016 In computer modeling, scopoletin showed strong ligand affinity and binding energies toward the following angiogenic factors: protein kinase (ERK1), vascular endothelial growth factor A (VEGF-A), and fibroblast growth factor 2 (FGF-2). Scopoletin 22-32 vascular endothelial growth factor A Homo sapiens 186-192 27133199-13 2016 These results suggest that the antitumor activity of scopoletin may be due to its strong anti-angiogenic effect, which may be mediated by its effective inhibition of ERK1, VEGF-A, and FGF-2. Scopoletin 53-63 vascular endothelial growth factor A Homo sapiens 172-178