PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26560363-0	2015	Regulation of iron homeostasis by the p53-ISCU pathway.	Iron	14-18	tumor protein p53	Homo sapiens	38-41	
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	35-39	tumor protein p53	Homo sapiens	21-24	
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	99-103	tumor protein p53	Homo sapiens	21-24	
26560363-2	2015	Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis.	Iron	200-202	tumor protein p53	Homo sapiens	21-24	
26560363-5	2015	In addition, in response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells.	Iron	110-114	tumor protein p53	Homo sapiens	40-43	
26560363-6	2015	HCT116 p53(+/+) cells were resistant to iron accumulation, but HCT116 p53(-/-) cells accumulated intracellular iron after DNA damage.	Iron	111-115	tumor protein p53	Homo sapiens	70-73	
26560363-9	2015	Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis.	Iron	80-84	tumor protein p53	Homo sapiens	41-44