PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26342080-3 2015 Down-regulation of SAMHD1 by siRNA expands all four dNTP pools, with dGTP undergoing the largest relative increase. deoxyguanosine triphosphate 69-73 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens 19-25 26342080-4 2015 The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase. deoxyguanosine triphosphate 43-47 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens 31-37 26342080-6 2015 We studied if SAMHD1 and dGK interact in the regulation of the dGTP pool during quiescence employing dGK-mutated skin fibroblasts derived from three unrelated patients. deoxyguanosine triphosphate 63-67 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens 14-20 26342080-11 2015 Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus. deoxyguanosine triphosphate 193-197 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens 36-42 26342080-11 2015 Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus. deoxyguanosine triphosphate 193-197 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens 210-216