PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26224795-7 2015 METHODS AND RESULTS: BRD4 is upregulated in lungs, distal PAs, and PASMCs of patients with PAH compared with controls. Protactinium 58-61 bromodomain containing 4 Homo sapiens 21-25 26224795-7 2015 METHODS AND RESULTS: BRD4 is upregulated in lungs, distal PAs, and PASMCs of patients with PAH compared with controls. pasmcs 67-73 bromodomain containing 4 Homo sapiens 21-25 26224795-9 2015 We further studied the molecular downstream targets of BRD4 by inhibiting its activity in PAH-PASMCs using a clinically available inhibitor JQ1. pah-pasmcs 90-100 bromodomain containing 4 Homo sapiens 55-59 26224795-10 2015 JQ1 treatment in PAH-PASMCs increased p21 expression, thus triggering cell cycle arrest. pasmcs 21-27 H3 histone pseudogene 16 Homo sapiens 38-41