PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26208523-0	2015	The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis.	Oxaliplatin	45-56	tumor protein p53	Homo sapiens	65-68	
26208523-3	2015	In the p53-proficient colorectal cancer cell line HCT116, oxaliplatin represses the expression of deoxyuridine triphosphatase (dUTPase), a ubiquitous pyrophosphatase that catalyzes the hydrolysis of dUTP to dUMP and inhibits dUTP-mediated cytotoxicity.	Oxaliplatin	58-69	tumor protein p53	Homo sapiens	7-10	
26208523-6	2015	Oxaliplatin induced early p53 accumulation, upregulation of primary miR-34a transcript expression, and subsequent downregulation of E2F3 and E2F1.	Oxaliplatin	0-11	tumor protein p53	Homo sapiens	26-29	
26208523-9	2015	In addition to DUT-N, oxaliplatin repressed, in a p53-dependent manner, the expression of genes encoding enzymes involved in thymidylate biosynthesis.	Oxaliplatin	22-33	tumor protein p53	Homo sapiens	50-53	
26208523-10	2015	Consequently, oxaliplatin significantly decreased the level of dTTP in the dNTP pool in a p53-dependent manner.	Oxaliplatin	14-25	tumor protein p53	Homo sapiens	90-93	
26208523-11	2015	These data indicate that the DACH carrier ligand in oxaliplatin triggers signaling via the p53-miR-34a-E2F axis, leading to transcriptional regulation that ultimately results in accumulation of dUTP and reduced dTTP biosynthesis, potentially enhancing 5-FU cytotoxicity.	Oxaliplatin	52-63	tumor protein p53	Homo sapiens	91-94