PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25981877-3 2015 Metformin may harbor a pleiotropic action, (a) decreasing inflammation (via anti COX 2 pathway and other mechanism), (b) decreasing COX 2 and VEGF mediated angiogenesis, (c) increasing negative angiogenic regulation pathway by stimulating SMAD 2/3 expression either directly or via the AMPK pathway and preventing from pulmonary hypertension development and (d) diminushin oxidative stress. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86 25981877-3 2015 Metformin may harbor a pleiotropic action, (a) decreasing inflammation (via anti COX 2 pathway and other mechanism), (b) decreasing COX 2 and VEGF mediated angiogenesis, (c) increasing negative angiogenic regulation pathway by stimulating SMAD 2/3 expression either directly or via the AMPK pathway and preventing from pulmonary hypertension development and (d) diminushin oxidative stress. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-137