PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2586490-7 1989 It was also inferred from these observations that the volume within the active site of FPGS above/below the pyrazine ring or near the 10-position of folate derivatives are regions of limited bulk tolerance; binding of folate analogs with substituents at these positions probably distorts the active site. Pyrazines 108-116 folylpolyglutamyl synthetase Mus musculus 87-91