PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25864748-4 2015 This study was undertaken to analyze whether disrupting the microtubule cytoskeleton by colchicine modulates transcriptional levels of MEFV, NF-kappaB p65, NLRP3, HMGB1, and caspase-3 in neutrophils from patients with familial Mediterranean fever (FMF) and healthy subjects. Colchicine 88-98 NLR family pyrin domain containing 3 Homo sapiens 156-161 25864748-5 2015 In the present study, colchicine caused increased expression of NLRP3 (p=0.007) and MEFV (p=0.03), but had no effect on caspase-3, NF-kappaB p65 and HMGB1 genes in healthy neutrophils. Colchicine 22-32 NLR family pyrin domain containing 3 Homo sapiens 64-69