PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25851902-10 2015 We conclude that modification of the functional groups attached to the D-ring of the hydrocortisone steroid molecule produces compounds with altered structure-function GR agonist activity with decreased impact on insulin secretion and reduced adipogenic potential but with preservation of anti-inflammatory activity. Steroids 100-107 insulin Homo sapiens 213-220