PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25700560-0	2015	SIRT5 regulation of ammonia-induced autophagy and mitophagy.	Ammonia	20-27	sirtuin 5	Homo sapiens	0-5	
25700560-1	2015	In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle.	Ammonia	52-59	sirtuin 5	Homo sapiens	36-41	
25700560-1	2015	In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle.	Ammonia	52-59	carbamoyl-phosphate synthase 1	Homo sapiens	89-93	
25700560-1	2015	In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle.	Urea	119-123	sirtuin 5	Homo sapiens	36-41	
25700560-1	2015	In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle.	Urea	119-123	carbamoyl-phosphate synthase 1	Homo sapiens	89-93	
25700560-3	2015	To address the possibility that SIRT5 is involved in ammonia production also in nonliver cells, clones of human breast cancer cell lines MDA-MB-231 and mouse myoblast C2C12, overexpressing or silenced for SIRT5 were produced.	Ammonia	53-60	sirtuin 5	Homo sapiens	32-37	
25700560-4	2015	Our results show that ammonia production increased in SIRT5-silenced and decreased in SIRT5-overexpressing cells.	Ammonia	22-29	sirtuin 5	Homo sapiens	54-59	
25700560-4	2015	Our results show that ammonia production increased in SIRT5-silenced and decreased in SIRT5-overexpressing cells.	Ammonia	22-29	sirtuin 5	Homo sapiens	86-91	
25700560-5	2015	We also obtained the same ammonia increase when using a new specific inhibitor of SIRT5 called MC3482.	Ammonia	26-33	sirtuin 5	Homo sapiens	82-87	
25700560-5	2015	We also obtained the same ammonia increase when using a new specific inhibitor of SIRT5 called MC3482.	MC3482	95-101	sirtuin 5	Homo sapiens	82-87	
25700560-6	2015	SIRT5 regulates ammonia production by controlling glutamine metabolism.	Ammonia	16-23	sirtuin 5	Homo sapiens	0-5	
25700560-6	2015	SIRT5 regulates ammonia production by controlling glutamine metabolism.	Glutamine	50-59	sirtuin 5	Homo sapiens	0-5	
25700560-9	2015	We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics.	Ammonia	66-73	microtubule associated protein 1 light chain 3 beta	Homo sapiens	164-172	
25700560-9	2015	We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics.	Ammonia	66-73	GABA type A receptor-associated protein	Homo sapiens	174-181	
25700560-9	2015	We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics.	Ammonia	66-73	GABA type A receptor associated protein like 2	Homo sapiens	187-196	
25700560-9	2015	We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics.	Ammonia	66-73	BCL2 interacting protein 3	Homo sapiens	216-221	
25700560-9	2015	We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics.	Ammonia	66-73	PTEN induced kinase 1	Homo sapiens	230-235	
25700560-9	2015	We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics.	Ammonia	66-73	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	236-241	
25700560-12	2015	In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism.	Ammonia	81-88	sirtuin 5	Homo sapiens	42-47	
25700560-12	2015	In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism.	Ammonia	104-111	sirtuin 5	Homo sapiens	42-47	
25700560-12	2015	In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism.	Glutamine	144-153	sirtuin 5	Homo sapiens	42-47