PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25643582-5 2015 Inhibition of the insulin/IGF-1 signaling system through genetic deletion of the insulin receptor alone or in combination with the IGF-1 receptor or treatment with rapamycin prevented hyperphosphorylation of S6RP without affecting the mitochondrial structural defect, alleviated renal disease, and delayed the onset of kidney failure in PHB2-deficient animals. Sirolimus 164-173 insulin Homo sapiens 18-25