PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25490093-0	2014	p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression.	Etoposide	56-65	tumor protein p53	Homo sapiens	0-3	
25490093-3	2014	In this study we evaluated the cascade of events determined by etoposide-induced DNA damage in OS cell lines with different p53 status focusing on methylation status and expression of miR-34a that modulate tumor cell growth and cell cycle progression.	Etoposide	63-72	tumor protein p53	Homo sapiens	124-127	
25490093-4	2014	Wild-type p53 U2-OS cells and U2-OS cells expressing dominant-negative form of p53 (U2- OS175) were more sensitive to etoposide than p53-deficient MG63 and Saos-2 cells, showing increased levels of unmethylated miR-34a, reduced expression of CDK4 and cell cycle arrest in G1 phase.	Etoposide	118-127	tumor protein p53	Homo sapiens	10-13	
25490093-4	2014	Wild-type p53 U2-OS cells and U2-OS cells expressing dominant-negative form of p53 (U2- OS175) were more sensitive to etoposide than p53-deficient MG63 and Saos-2 cells, showing increased levels of unmethylated miR-34a, reduced expression of CDK4 and cell cycle arrest in G1 phase.	Etoposide	118-127	tumor protein p53	Homo sapiens	79-82	
25490093-4	2014	Wild-type p53 U2-OS cells and U2-OS cells expressing dominant-negative form of p53 (U2- OS175) were more sensitive to etoposide than p53-deficient MG63 and Saos-2 cells, showing increased levels of unmethylated miR-34a, reduced expression of CDK4 and cell cycle arrest in G1 phase.	Etoposide	118-127	tumor protein p53	Homo sapiens	79-82	
25490093-6	2014	Consistently, in p53siRNA transfected U2-OS cells we observed loss of miR-34a induction after etoposide exposure associated with a partial gain of gene methylation and cell cycle progress towards G2/M phase.	Etoposide	94-103	tumor protein p53	Homo sapiens	17-20	
25490093-8	2014	In conclusion, cell response to etoposide-induced DNA damage was not compromised in cells with dominant-negative p53 expression.	Etoposide	32-41	tumor protein p53	Homo sapiens	113-116