PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25456436-6 2014 RESULT: BER significantly increased the metabolism of midazolam, phenacetin and tolbutamide by inducing the CYP1A2 and 3A4 enzyme in a dose-dependent manner, the mRNA and protein expression of CYP1A2 and 3A4 were increased by berberine at 1000ng mL(-1). Phenacetin 65-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 108-114 25456436-6 2014 RESULT: BER significantly increased the metabolism of midazolam, phenacetin and tolbutamide by inducing the CYP1A2 and 3A4 enzyme in a dose-dependent manner, the mRNA and protein expression of CYP1A2 and 3A4 were increased by berberine at 1000ng mL(-1). Phenacetin 65-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 193-199 25456436-8 2014 CONCLUSION: BER increases the metabolism of cocktail drugs such as midazolam, phenacetin and tolbutamide by increasing the mRNA and protein expression of CYP1A2 and 3A4. Phenacetin 78-88 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 154-160