PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25409894-0 2015 Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. Phenobarbital 91-104 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-26 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Phenobarbital 30-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-26 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Phenobarbital 45-47 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-26 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Phenobarbital 45-47 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-98 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Phenobarbital 45-47 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-98 25409894-3 2015 Hepatic expression of CYP2B6 mRNA and protein was greatly induced by PB or DEX treatment in both TG and TG/Cyp2abfgs-null mice. Phenobarbital 69-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 22-28 25409894-5 2015 In PB-treated mice, the rates of hepatic microsomal hydroxybupropion formation (at 50 muM bupropion) were >4-fold higher in TG/Cyp2abfgs-null than in Cyp2abfgs-null mice (for both male and female mice); the rate difference was accompanied by a 5-fold higher catalytic efficiency in the TG/Cyp2abfgs-null mice and was abolished by an antibody to CYP2B6. Phenobarbital 3-5 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 348-354