PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25400942-0	2014	Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes.	Leucine	0-7	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	53-57	
25400942-2	2014	Moreover, beta-hydroxy-beta-methyl butyrate (HMB), a metabolite of leucine, has been reported to activate AMPK synergistically with resveratrol in C2C12 myotubes.	Leucine	67-74	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	106-110	
25400942-3	2014	Therefore, we hypothesize that leucine-induced activation of SIRT1 and AMPK is the central event that links the upregulated mitochondrial biogenesis and fatty acid oxidation in skeletal muscle.	Leucine	31-38	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	71-75	
25400942-6	2014	Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.	Leucine	13-20	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	123-127	
25400942-6	2014	Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.	Leucine	13-20	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	175-179	
25400942-6	2014	Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.	Leucine	13-20	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	175-179	
25400942-6	2014	Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.	Leucine	197-204	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	123-127	
25400942-6	2014	Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.	Leucine	197-204	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	175-179	
25400942-6	2014	Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.	Leucine	197-204	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	175-179